Reactive Oxygen Species-Induced Lipid Peroxidation in Apoptosis, Autophagy, and Ferroptosis

Oxid Med Cell Longev. 2019 Oct 13;2019:5080843. doi: 10.1155/2019/5080843. eCollection 2019.


Reactive oxygen species- (ROS-) induced lipid peroxidation plays a critical role in cell death including apoptosis, autophagy, and ferroptosis. This fundamental and conserved mechanism is based on an excess of ROS which attacks biomembranes, propagates lipid peroxidation chain reactions, and subsequently induces different types of cell death. A highly evolved sophisticated antioxidant system exists that acts to protect the cells from oxidative damage. In this review, we discussed how ROS propagate lipid peroxidation chain reactions and how the products of lipid peroxidation initiate apoptosis and autophagy in current models. We also discussed the mechanism of lipid peroxidation during ferroptosis, and we summarized lipid peroxidation in pathological conditions of critical illness. We aim to bring a more global and integrative sight to know how different ROS-induced lipid peroxidation occurs among apoptosis, autophagy, and ferroptosis.

Publication types

  • Review

MeSH terms

  • Acute Kidney Injury / metabolism*
  • Animals
  • Antioxidants / metabolism
  • Apoptosis
  • Autophagy
  • Ferroptosis
  • Humans
  • Lipid Peroxidation / physiology*
  • Oxidative Stress
  • Reactive Oxygen Species / metabolism
  • Sepsis / metabolism*
  • Signal Transduction


  • Antioxidants
  • Reactive Oxygen Species