Fabrication of a Hydrazone-Based Al(III)-Selective "Turn-On" Fluorescent Chemosensor and Ensuing Potential Recognition of Picric Acid

Sanyog Sharma; Gurudutt Dubey; Balkaran Singh Sran; Prasad V Bharatam; Geeta Hundal

doi:10.1021/acsomega.9b02132

Fabrication of a Hydrazone-Based Al(III)-Selective "Turn-On" Fluorescent Chemosensor and Ensuing Potential Recognition of Picric Acid

ACS Omega. 2019 Oct 29;4(20):18520-18529. doi: 10.1021/acsomega.9b02132. eCollection 2019 Nov 12.

Authors

Sanyog Sharma¹, Gurudutt Dubey², Balkaran Singh Sran¹, Prasad V Bharatam², Geeta Hundal¹

Affiliations

¹ Department of Chemistry, UGC Center for Advance Studies, Guru Nanak Dev University, Amritsar 143005, Punjab, India.
² Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, S.A.S. Nagar 160062, Punjab, India.

Abstract

A hydrazone-based N'1,N'3-bis((E)-4-(diethylamino)-₂ ^-hydroxybenzylidene)isophthalohydrazide (NDHIPH), has been synthesized, characterized, and assessed for its highly selective and sensitive (limit of detection, 2.53 nM) response toward Al(III) via fluorescence enhancement in 95% aqueous medium. All experimental results of analytical studies are in good consonance with the theoretical studies performed. Further, this NDHIPH-Al(III) ensemble is used for selective and sensitive (12.15 nM) detection of explosive picric acid (PA) via fluorescence quenching. This reversible behavior of NDHIPH toward Al(III) and PA is used for the creation of a molecular logic gate.