Background: High-fat meal (HFM) consumption may induce transient postprandial atherogenic responses, including impairment of vascular endothelial function, in individuals with overweight/obesity. Red beetroot juice (RBJ) may modulate endothelial function and other measures of cardiometabolic health.
Objective: This study investigated the impact of acute and chronic RBJ consumption, including nitrate-dependent and -independent effects, on postprandial endothelial function and other cardiometabolic responses to a HFM.
Methods: Fifteen men and postmenopausal women with overweight/obesity were enrolled in this randomized, double-blind, placebo-controlled, 4-period, crossover clinical trial. Following an overnight fast, participants underwent baseline assessment of endothelial function (reactive hyperemia index; RHI) and hemodynamics, and biological sample collection. In random order, participants consumed 70 mL (acute visit) of: 1) RBJ, 2) nitrate-free RBJ (NF-RBJ), 3) placebo + nitrate (PBO + NIT), or 4) placebo (PBO), followed by a HFM. RHI was remeasured 4 h post-HFM, and hemodynamic assessment and biological sample collection were performed 1, 2, and 4 h post-HFM consumption. Participants consumed treatments daily for 4 wk (chronic visit), and assessments were repeated before/after the HFM (without consuming treatments).
Results: HFM consumption did not induce significant impairment of postprandial RHI. No significant differences in RHI were detected across treatment groups following acute or chronic exposure, despite increases in circulating nitrate/nitrite (NOx) concentrations in the RBJ and PBO + NIT groups compared with PBO and NF-RBJ (P < 0.0001 for all time points at the acute visit; P < 0.05 for all time points at the chronic visit). Although the HFM led to significant alterations in several secondary outcomes, there were no consistent treatment effects on postprandial cardiometabolic responses.
Conclusions: HFM consumption did not impair postprandial endothelial function in this population, and RBJ exposure did not alter postprandial endothelial function or other outcomes despite increasing NOx concentrations. This trial is registered at clinicaltrials.gov as NCT02949115.
Keywords: betalains; cardiovascular disease; dietary nitrate; inflammation; nitric oxide; oxidative stress; postprandial dysmetabolism; vascular function; vasodilation.
Copyright © The Author(s) 2019.
Beetroot Juice Improves in Overweight and Slightly Obese Men Postprandial Endothelial Function After Consumption of a Mixed MealPJ Joris et al. Atherosclerosis 231 (1), 78-83. PMID 24125415. - Randomized Controlled TrialIn healthy overweight and slightly obese men a single dose of beetroot juice attenuates the postprandial impairment of FMD following a mixed meal, possibly through increa …
l-Arginine Supplementation Alleviates Postprandial Endothelial Dysfunction When Baseline Fasting Plasma Arginine Concentration Is Low: A Randomized Controlled Trial in Healthy Overweight Adults With Cardiometabolic Risk FactorsA Deveaux et al. J Nutr 146 (7), 1330-40. PMID 27281800. - Randomized Controlled TrialSupplementation with low-dose SR-arginine alleviates postprandial endothelial dysfunction in healthy HTW adults when the baseline plasma arginine concentration is relativ …
Consumption of Mixed Fruit-Juice Drink and Vitamin C Reduces Postprandial Stress Induced by a High Fat Meal in Healthy Overweight SubjectsI Peluso et al. Curr Pharm Des 20 (6), 1020-4. PMID 23701571. - Randomized Controlled TrialPostprandial stress induced by acute consumption of meals with a high fat content results in an increase of markers of cardiometabolic risk. Repeated acute dietary stress …
Supplementation With Resveratrol and Curcumin Does Not Affect the Inflammatory Response to a High-Fat Meal in Older Adults With Abdominal Obesity: A Randomized, Placebo-Controlled Crossover TrialC Vors et al. J Nutr 148 (3), 379-388. PMID 29546309. - Randomized Controlled TrialAcute supplementation with Res/Cur has no impact on the postprandial inflammation response to a high-fat meal in abdominally obese older adults. Further studies are warra …
Functional Properties of Beetroot ( Beta vulgaris) in Management of Cardio-Metabolic DiseasesP Mirmiran et al. Nutr Metab (Lond) 17, 3. PMID 31921325. - ReviewRed beetroot (Beta vulgaris), as a naturally occurring root vegetable and a rich source of phytochemicals and bioactive compounds, is known for its beneficial role …
- Lakatta EG. Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: part III: cellular and molecular clues to heart and arterial aging. Circulation 2003;107(3):490–7. - PubMed
- Botham KM, Wheeler-Jones CP. Postprandial lipoproteins and the molecular regulation of vascular homeostasis. Prog Lipid Res 2013;52(4):446–64. - PubMed
- O'Keefe JH, Bell DS. Postprandial hyperglycemia/hyperlipidemia (postprandial dysmetabolism) is a cardiovascular risk factor. Am J Cardiol 2007;100(5):899–904. - PubMed