Fat Grafting for Facial Rejuvenation with Nanofat Grafts

Clin Plast Surg. 2020 Jan;47(1):53-62. doi: 10.1016/j.cps.2019.08.006. Epub 2019 Oct 28.


Reversing structural changes in aging skin gained potential after the therapeutic use of adipose-derived stem cells was described. Nanofat is a highly concentrated solution of progenitor cells without viable adipocytes. Nanofat grafting creates striking skin quality improvement. The availability of adipose-tissue combined with straightforward mechanical protocol to process fat brings regenerative and antiaging medicine into real-life clinical practice. Association with other cofactors (hyaluronic acid, botulin toxin, and vitamin C) and therapies (microneedling and drug delivery) provides better outcomes. This article describes the techniques and the authors' experiences in nanofat grafting, and its potential new applications in regenerative medicine.

Keywords: Antiaging; Nanofat; Needling; Regenerative; Rejuvenation; Stem cell.

Publication types

  • Review

MeSH terms

  • Adipocytes / transplantation
  • Adipose Tissue / transplantation*
  • Face / surgery*
  • Humans
  • Plastic Surgery Procedures*
  • Regenerative Medicine / methods*
  • Rejuvenation
  • Skin Aging
  • Stem Cell Transplantation*
  • Stem Cells