Gynecologic Malignancies

Hematol Oncol Clin North Am. 2020 Feb;34(1):71-89. doi: 10.1016/j.hoc.2019.08.018.


Gynecologic malignancies are among the most prevalent cancers affecting women worldwide, but they are heterogeneous diseases with varying risk factors, management paradigms, and outcomes. Gynecologic cancers mediated by human papillomavirus (HPV) are preventable and curable with early detection and treatment. Dramatic reductions in cervical cancer incidence and mortality have been achieved through cancer screening and HPV vaccination. Radiotherapy plays a central role in the management of gynecologic malignancies. For some cancers, radiotherapy alone can be curative. More often, radiotherapy is used in conjunction with surgery and systemic therapy to improve locoregional control and extend overall survival. This chapter reviews recent advances in radiotherapeutic management of gynecologic malignancies.

Keywords: Brachytherapy; Cervical cancer; Image guidance; Intensity modulated radiotherapy; Uterine cancer; Vulvar cancer.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Disease-Free Survival
  • Early Detection of Cancer*
  • Female
  • Genital Neoplasms, Female* / diagnosis
  • Genital Neoplasms, Female* / mortality
  • Genital Neoplasms, Female* / radiotherapy
  • Humans
  • Papillomavirus Infections* / diagnosis
  • Papillomavirus Infections* / mortality
  • Papillomavirus Infections* / radiotherapy
  • Survival Rate