A prospective, randomized, clinical trial of heparin therapy for postoperative intraocular fibrin

Ophthalmology. 1988 Mar;95(3):312-7. doi: 10.1016/s0161-6420(88)33181-7.


The authors undertook a study to investigate the ability of systemic or heparin supplementation of the vitrectomy infusion solution to prevent formation of postoperative intraocular fibrin membranes. A total of 73 eyes were randomized; 26 served as the control group, 23 received 10,000 IU of intravenous bolus of heparin, and 12 eyes each underwent the vitrectomy with an infusion solution containing 10 or 5 IU/cc of heparin. Intraoperative bleeding, postoperative bleeding, and postoperative fibrin formation were graded. A 10-IU/cc heparin infusion resulted in a statistically significant reduction in postoperative fibrin formation (P = 0.04) but increased intraoperative bleeding (P = 0.02). A trend toward reduced postoperative fibrin formation was noted in the intravenous heparin and 5 IU/cc infusion groups.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Fibrin / metabolism*
  • Heparin / administration & dosage
  • Heparin / therapeutic use*
  • Humans
  • Infusions, Intravenous
  • Injections, Intravenous
  • Intraoperative Complications / etiology
  • Postoperative Complications / prevention & control*
  • Prospective Studies
  • Random Allocation
  • Thrombosis / prevention & control
  • Vitrectomy / adverse effects*
  • Vitreous Hemorrhage / etiology


  • Fibrin
  • Heparin