Fe-N/C single-atom catalysts exhibiting multienzyme activity and ROS scavenging ability in cells

Chem Commun (Camb). 2019 Nov 28;55(96):14534-14537. doi: 10.1039/c9cc07408b.

Abstract

Fe-N/C single atom catalysts (SACs) exhibit peroxidase-like, oxidase-like, catalase-like, and glutathione peroxidase-like activity. Fe-N/C SACs are successfully applied to control the intracellular H2O2 level. This study not only explores the types of SACs mimicking enzymes but also provides opportunities for SACs in biomedical and other bioengineering applications.

MeSH terms

  • Biomimetic Materials / chemistry*
  • Biomimetic Materials / metabolism
  • Biomimetic Materials / pharmacology
  • Carbon / chemistry*
  • Catalase / chemistry
  • Catalase / metabolism
  • Catalysis
  • Cell Survival / drug effects
  • Glutathione Peroxidase / chemistry
  • Glutathione Peroxidase / metabolism
  • HeLa Cells
  • Humans
  • Hydrogen Peroxide / chemistry
  • Hydrogen Peroxide / metabolism
  • Iron / chemistry*
  • Nitrogen / chemistry*
  • Oxidation-Reduction
  • Porphyrins / chemistry
  • Reactive Oxygen Species / chemistry*
  • Reactive Oxygen Species / metabolism

Substances

  • Porphyrins
  • Reactive Oxygen Species
  • tetraphenylporphyrin
  • Carbon
  • Hydrogen Peroxide
  • Iron
  • Catalase
  • Glutathione Peroxidase
  • Nitrogen