Association of leukemia and mitochondrial diseases-A review

Ashwani Sachdeva; Jagadish Prasad Rajguru; Kanwardeep Sohi; Swati Saggar Sachdeva; Kirandeep Kaur; Rani Devi; Vivek Rana

doi:10.4103/jfmpc.jfmpc_679_19

Association of leukemia and mitochondrial diseases-A review

J Family Med Prim Care. 2019 Oct 31;8(10):3120-3124. doi: 10.4103/jfmpc.jfmpc_679_19. eCollection 2019 Oct.

Authors

Ashwani Sachdeva¹, Jagadish Prasad Rajguru², Kanwardeep Sohi³, Swati Saggar Sachdeva¹, Kirandeep Kaur⁴, Rani Devi⁴, Vivek Rana⁵

Affiliations

¹ Department of Prosthodontics, J.C.D Dental College, Sirsa, Haryana, India.
² Department of Oral and Maxillofacial Pathology, Hi-Tech Dental College and Hospital, Bhubaneswar, Odisha, India.
³ Department of Prosthodontics, Shaheed Kartar Singh Sarabha Dental College and Hospital, Sarabha, Ludhiana, Punjab, India.
⁴ Department of Public Health Dentistry, Shaheed Kartar Singh Sarabha Dental College and Hospital, Sarabha, Ludhiana, Punjab, India.
⁵ Department of Oral Medicine, Private Practitioner, New Delhi, India.

Abstract

Mitochondria play an important role in various metabolic pathways like oxidative phosphorylation free radical generation and apoptosis. Defects in mitochondrial function are responsible for a number of heterogenous clinical presentations along with development and progression of cancer. Decrease in cellular energy (ATP) production because of impaired oxidative phosphorylation is the most important cause for these underlying disorders. The present review article aims to provide current understanding of mitochondrial genetics and biology and relates the mt-DNA alterations in leukemia patients.

Keywords: Leukemia; mitochondrial DNA; oxidative phosphorylation.

Publication types

Review