Dysregulation of multisensory processing stands out from an early stage of migraine: a study in pediatric patients

J Neurol. 2020 Mar;267(3):760-769. doi: 10.1007/s00415-019-09639-9. Epub 2019 Nov 19.

Abstract

Resting state (RS) functional connectivity (FC) abnormalities of brain networks involved in pain- and multisensory processing have been disclosed in adult-migraine patients. We explored RS FC of large-scale brain networks in pediatric-migraine patients and their correlation with patients' clinical characteristics. RS functional MRI data was acquired from 13 pediatric-migraine patients and 14 age- and sex-matched controls. Intra- and inter-network RS FC differences between patients and controls were evaluated. Correlations between RS FC abnormalities and patients' clinical characteristics were also assessed. Compared to controls, pediatric-migraine patients had a decreased RS FC of the left parieto-occipital junction of the default mode network (DMN) and left-dorsolateral prefrontal cortex of the executive control network (ECN). They also experienced an increased RS FC of the right frontopolar cortex of the right frontoparietal network (FPN) and the right-middle occipital gyrus of the secondary visual network. A significant stronger connectivity between the ECN and primary visual network and between the right FPN and primary sensorimotor, primary visual and auditory networks were found in migraine patients compared to controls. A significant weaker connectivity between the DMN and right FPN was revealed in migraineurs compared to controls. No correlation was found between intra- and inter-network RS FC abnormalities and patients' clinical characteristics. Pediatric-migraine patients harbor significant RS FC abnormalities in brain networks involved in multisensory processing and in the cognitive control of pain. An early dysregulation of multisensory processing, including pain, might represent a phenotypic biomarker of the disease.

Keywords: Brain networks; Migraine; Pediatric migraine; Resting state functional MRI.

MeSH terms

  • Adolescent
  • Brain / physiopathology*
  • Brain Mapping / methods
  • Child
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Migraine Disorders / physiopathology*
  • Nerve Net / physiopathology*
  • Neural Pathways / physiopathology*