Effectiveness of Stem Cell Therapy in the Treatment of Ovarian Disorders and Female Infertility: A Systematic Review

Curr Stem Cell Res Ther. 2020;15(2):173-186. doi: 10.2174/1574888X14666191119122159.


Background: Infertility is a major problem worldwide. Various strategies are being used to develop better treatments for infertility and The most trending strategy is the stem cell therapy. In this study, the literature on stem cell therapy for ovarian disorders is summarized with analysis of current developments.

Objective: Different published studies on stem cell-based therapy for the treatment of various types of ovarian insufficiency and disorders such as Premature Ovarian Insufficiency (POI) in the affected female population in animal or human clinical studies are systematically reviewed.

Methods: We monitored five databases, including PubMed, Cochrane, Embase, Scopus, and ProQuest. A comprehensive online search was done using the criteria targeting the application of stem cells in animal models for menopause. Two independent reviewers carefully evaluated titles and abstracts of studies. The stem cell type, source, dosage, route of administration were highlighted in various POI animals models. Non-relevant and review articles were excluded.

Outcomes: 648 published studies were identified during the initial comprehensive search process from which 41 were selected according to designed criteria. Based on our analysis, stem cells could accelerate ovarian tissues rejuvenation, regulate systemic sex-related hormones levels and eventually increase fertility rate.

Conclusion: The evidence suggests that stem cell-based therapies could be considered as an alternative modality to deal with women undergoing POI.

Keywords: Stem cell therapy; infertility; ovarian disorder; ovarian tissue; premature ovarian insufficiency; transplantation..

Publication types

  • Systematic Review

MeSH terms

  • Animals
  • Female
  • Humans
  • Infertility, Female / therapy*
  • Primary Ovarian Insufficiency / therapy*
  • Stem Cell Transplantation* / methods
  • Stem Cell Transplantation* / trends
  • Stem Cells / physiology
  • Treatment Outcome