Oleuropein: A natural antioxidant molecule in the treatment of metabolic syndrome

Phytother Res. 2019 Dec;33(12):3112-3128. doi: 10.1002/ptr.6511. Epub 2019 Nov 20.


Olive (Olea europaea Linn., Fam. Oleaceae) is commonly known as Zaytoon in Mediterranean region. Its fruits and oil are essential components of Mediterranean diets. Olive tree is a prevalent plant species and one of the important cultivated crops of Mediterranean region. Oleuropein is a phenolic constituents of olive, which, along with its related compounds, has been indicated to be majorly responsible for its beneficial effects. Oleuropein is a secoiridoid type of phenolic compound and consists of three structural subunits: hydroxytyrosol, elenolic acid, and a glucose molecule. It is also reported to be the chemotaxonomic marker of olive. The oleuropein is reported to possess a number of biological activities including action against dyslipidemia, antiobesity, antidiabetic, antioxidant, antiatherogenic, antihypertensive, antiinflammatory, and hepatoprotective actions. The scientific evidence supports the role of oleuropein as a potential agent against metabolic syndrome. The present review discusses chemistry of oleuropein along with potential role of oleuropein with reference to pathophysiology of metabolic syndrome.

Keywords: Olea europaea L; cardiovascular disease; chemistry; diabetes; metabolic syndrome; obesity; oleuropein.

Publication types

  • Review

MeSH terms

  • Adolescent
  • Adult
  • Antioxidants / pharmacology
  • Antioxidants / therapeutic use*
  • Humans
  • Iridoid Glucosides
  • Iridoids / pharmacology
  • Iridoids / therapeutic use*
  • Metabolic Syndrome / diet therapy*
  • Young Adult


  • Antioxidants
  • Iridoid Glucosides
  • Iridoids
  • oleuropein