5-HT2AR and BDNF gene variants in eating disorders susceptibility

Am J Med Genet B Neuropsychiatr Genet. 2020 Apr;183(3):155-163. doi: 10.1002/ajmg.b.32771. Epub 2019 Nov 20.


Evidence from family and twin studies points to a genetic contribution to the etiology of eating disorders (EDs), confirmed by the association of several single nucleotide polymorphisms (SNPs) with this group of disorders. Previous reports have suggested that the serotonin receptor (5-HT2AR) and brain-derived neurotrophic factor (BDNF) genes could be both involved in EDs susceptibility. In order to provide further evidence about such association, we focused our attention on two SNPs located in these genes carrying out a genetic association study on a large Italian cohort composed of 556 ED patients and 355 controls (CTRs). Obtained results confirm the presence of an association between 5-HT2AR and BDNF genes and the susceptibility to EDs.

Keywords: 5-HT2AR; BDNF; anorexia nervosa; binge eating; bulimia nervosa.

MeSH terms

  • Adolescent
  • Adult
  • Brain-Derived Neurotrophic Factor / genetics*
  • DNA Methylation
  • Family Health
  • Feeding and Eating Disorders / genetics*
  • Female
  • Genetic Association Studies
  • Genetic Predisposition to Disease*
  • Genotype
  • Humans
  • Italy
  • Male
  • Middle Aged
  • Odds Ratio
  • Polymorphism, Single Nucleotide*
  • Receptor, Serotonin, 5-HT2A / genetics*
  • Young Adult


  • Brain-Derived Neurotrophic Factor
  • HTR2A protein, human
  • Receptor, Serotonin, 5-HT2A
  • BDNF protein, human