The Swedish Twin Registry: Content and Management as a Research Infrastructure

Twin Res Hum Genet. 2019 Dec;22(6):672-680. doi: 10.1017/thg.2019.99. Epub 2019 Nov 21.

Abstract

The Swedish Twin Registry functions as research infrastructure containing information on 216,258 twins born between 1886 and 2015, of whom 86,199 pairs have zygosity determined by DNA, an intrapair similarity algorithm, or being of opposite sex. In essence, practically all twins alive and currently 9 years or older have been invited for participation and donation of DNA on which genomewide single nucleotide polymorphisms array genotyping has been performed. Content, management and alternatives for future improvements are discussed.

Keywords: Sweden; Twin; biobank; environment; genetics; population-based; registry.

Publication types

  • Research Support, Non-U.S. Gov't
  • Twin Study

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Child
  • Child, Preschool
  • Data Management*
  • Diseases in Twins / epidemiology*
  • Diseases in Twins / genetics
  • Female
  • Follow-Up Studies
  • Genetic Markers*
  • Genotype
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide*
  • Registries / statistics & numerical data*
  • Research Design
  • Surveys and Questionnaires
  • Sweden / epidemiology
  • Twins, Dizygotic / genetics*
  • Twins, Monozygotic / genetics*
  • Whole Genome Sequencing
  • Young Adult

Substances

  • Genetic Markers