Ultrasensitive and visible light-responsive photoelectrochemical aptasensor for edifenphos based on Zinc phthalocyanine sensitized MoS2 nanosheets

Lijun Ding; Ding Jiang; Zuorui Wen; Yuhuan Xu; Yingshu Guo; Caifeng Ding; Kun Wang

doi:10.1016/j.bios.2019.111867

Ultrasensitive and visible light-responsive photoelectrochemical aptasensor for edifenphos based on Zinc phthalocyanine sensitized MoS₂ nanosheets

Biosens Bioelectron. 2020 Feb 15:150:111867. doi: 10.1016/j.bios.2019.111867. Epub 2019 Nov 12.

Authors

Lijun Ding¹, Ding Jiang¹, Zuorui Wen¹, Yuhuan Xu¹, Yingshu Guo², Caifeng Ding³, Kun Wang⁴

Affiliations

¹ Key Laboratory of Modern Agriculture Equipment and Technology, School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang, 212013, PR China.
² Collaborative Innovation Center of Tumor Marker Detection Technology, Equipment and Diagnosis-Therapy Integration in Universities of Shandong, Shandong Province Key Laboratory of Detection Technology for Tumor Makers, School of Chemistry and Chemical Engineering, Linyi University, Linyi, 276005, PR China. Electronic address: yingshug@126.com.
³ Qingdao University of Science and Technology, Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science, MOE, College of Chemistry and Molecular Engineering, Qingdao, 266042, PR China.
⁴ Key Laboratory of Modern Agriculture Equipment and Technology, School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang, 212013, PR China; Qingdao University of Science and Technology, Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science, MOE, College of Chemistry and Molecular Engineering, Qingdao, 266042, PR China. Electronic address: wangkun@ujs.edu.cn.

PMID: 31748191
DOI: 10.1016/j.bios.2019.111867

Abstract

Developing a simple, rapid detection method for the analysis of edifenphos (EDI) is crucial due to its residue is harmful to acetylcholinesterase on the human cellular system, and cause a lot of complications. Herein, we synthesized visible light-responsive MoS₂ nanosheets decorated with Zinc phthalocyanine (ZnPc) nanoparticles (ZnPc/n-MoS₂). Due to the sensitization of ZnPc nanoparticles, the resulting ZnPc/n-MoS₂ exhibited narrower energy bandgap and efficient charge transfer. Especially, the carrier lifetime of ZnPc/n-MoS₂ is 2 more times longer than n-MoS₂, and the photocurrent intensity of ZnPc/n-MoS₂ is 24 times of n-MoS₂ and 22 times of ZnPc nanoparticles under visible light irradiation. Further, a visible light-responsive ultrasensitive photoelectrochemical (PEC) aptasensor for selectivity recognition of EDI was triumphantly established by using EDI aptamer as a biorecognition element, which exhibited a wide linear ranking from 5 ng L^-1 to 10 μg L^-1 (R² = 0.996) and a low detection limit of 1.667 ng L^-1 (S/N = 3). The splendid performance of the ZnPc/n-MoS₂ nanosheet ultrasensitive sensing platform can be applied to detect the concentration of EDI in food, biomedical and environmental analysis.

Keywords: Edifenphos; Molybdenum disulfide; Photoelectric aptasensor; Visible light.

MeSH terms

Acetylcholinesterase / chemistry
Aptamers, Nucleotide / chemistry
Biosensing Techniques*
Electrochemical Techniques*
Humans
Indoles / chemistry*
Isoindoles
Light
Limit of Detection
Molybdenum / chemistry
Organometallic Compounds / chemistry*
Organothiophosphorus Compounds / chemistry
Organothiophosphorus Compounds / isolation & purification*
Organothiophosphorus Compounds / toxicity
Zinc Compounds

Substances

Aptamers, Nucleotide
Indoles
Isoindoles
Organometallic Compounds
Organothiophosphorus Compounds
Zinc Compounds
Zn(II)-phthalocyanine
edifenphos
Molybdenum
Acetylcholinesterase