Potential microRNA-related targets in clearance pathways of amyloid-β: novel therapeutic approach for the treatment of Alzheimer's disease

Soheil Madadi; Heidi Schwarzenbach; Massoud Saidijam; Reza Mahjub; Meysam Soleimani

doi:10.1186/s13578-019-0354-3

Potential microRNA-related targets in clearance pathways of amyloid-β: novel therapeutic approach for the treatment of Alzheimer's disease

Cell Biosci. 2019 Nov 12:9:91. doi: 10.1186/s13578-019-0354-3. eCollection 2019.

Authors

Soheil Madadi¹, Heidi Schwarzenbach², Massoud Saidijam³, Reza Mahjub⁴, Meysam Soleimani¹

Affiliations

¹ 1Department of Pharmaceutical Biotechnology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran.
² 2Department of Tumor Biology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
³ 3Department of Genetics and Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
⁴ 4Department of Pharmaceutics, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran.

Abstract

Imbalance between amyloid-beta (Aβ) peptide synthesis and clearance results in Aβ deregulation. Failure to clear these peptides appears to cause the development of Alzheimer's disease (AD). In recent years, microRNAs have become established key regulators of biological processes that relate among others to the development and progression of neurodegenerative diseases, such as AD. This review article gives an overview on microRNAs that are involved in the Aβ cascade and discusses their inhibitory impact on their target mRNAs whose products participate in Aβ clearance. Understanding of the mechanism of microRNA in the associated signal pathways could identify novel therapeutic targets for the treatment of AD.

Keywords: Autophagy; Aβ-degrading proteases; BBB transporters; Heat shock proteins; Phagocytosis; Ubiquitin–proteasome system; microRNAs.

Publication types

Review