Background: The primary aim of the present study was to investigate the effects of aerobic interval training (AIT) versus moderate intensity continuous exercise (MICE) on aerobic exercise capacity (V̇O2peak), in women only, with coronary artery disease (CAD) and who were referred to a large, 24-week outpatient cardiac rehabilitation (CR) programme. Secondary objectives included comparing the effects of AIT versus MICE on cognition, cardiovascular risk profile, adherence and quality of life before and after the 24-week CR programme.
Methods: Thirty-one postmenopausal women with CAD (left ventricular ejection fraction >35%; 68.2±9.2 years of age; V̇O2peak: 19.1±3.5 mL kg-1 min-1) were randomised to 24 weeks of usual care MICE (60%-80% of V̇O2peak, five times per week) or AIT (four 4-min intervals at 90%-95% of peak heart rate, three times per week+two times per week usual care MICE). Differences between and within groups were assessed using independent samples t-tests and paired samples t-tests, respectively. Treatment effect analysis of AIT on V̇O2peak and secondary outcomes was determined using analysis of covariance with baseline values as covariates.
Results: A randomised controlled trial study design was unfeasible in this female CAD population. Unanticipated challenges in recruitment availability and eligibility, in combination with a 59% and 50% attrition rate in the AIT and MICE group, respectively, rendered this study underpowered to detect differences between groups. The per protocol treatment effect analysis, however, unveiled a 0.95 mL kg-1 min-1 improvement in V̇O2peak in response to AIT over MICE (p<0.001).
Conclusions: Further research is necessary to elucidate the patient profile and circumstances under which the potential for the implementation of AIT may be individualised, and offered in clinical practice.
Trial registration: NCT02966158.
Keywords: aerobic exercise capacity; cardiac rehabilitation; coronary artery disease; interval training; women.
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Conflict of interest statement
Competing interests: None declared.
The Effectiveness of Progressive Aerobic Interval Training in Cardiac RehabilitationLS Lee et al. Med Sci Sports Exerc 50 (5), 881-888. PMID 29257009.Progressive AIT performed in a standard, outpatient CR program appears to be superior to usual care MICE for improving V˙O2peak, CV risk profile characteristics, and depr …
Aerobic Interval Training and Continuous Training Equally Improve Aerobic Exercise Capacity in Patients With Coronary Artery Disease: The SAINTEX-CAD StudyVM Conraads et al. Int J Cardiol 179, 203-10. PMID 25464446. - Randomized Controlled TrialContrary to earlier smaller trials, we observed similar improvements in exercise capacity and peripheral endothelial function following AIT and ACT in a large population …
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Exercise-based Cardiac Rehabilitation in Heart Transplant RecipientsL Anderson et al. Cochrane Database Syst Rev 4 (4), CD012264. PMID 28375548. - ReviewWe found moderate quality evidence suggesting that exercise-based cardiac rehabilitation improves exercise capacity, and that exercise has no impact on health-related qua …
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