Weight loss efficacy of alternate day fasting versus daily calorie restriction in subjects with subclinical hypothyroidism: a secondary analysis

Appl Physiol Nutr Metab. 2020 Mar;45(3):340-343. doi: 10.1139/apnm-2019-0554. Epub 2019 Nov 21.


This study compared the weight loss efficacy of alternate-day fasting (ADF) versus daily calorie restriction (CR) in adults with subclinical hypothyroidism. After 6 months, body weight decreased (P < 0.001) similarly by ADF (-7% ± 1%) and CR (-8% ± 2%). Insulin resistance decreased (P < 0.05) more by ADF versus CR. Free thyroxin and thyroid-stimulating hormone remained unchanged. Thus, ADF and CR produce similar weight loss in this population, without affecting thyroid hormone levels. Novelty Intermittent fasting and daily restriction produce similar reductions in body weight in subjects with subclinical hypothyroidism.

Keywords: alternate-day fasting; calorie restriction; hypothyroïdie infraclinique; insulin resistance; insulinorésistance; jeûne intermittent; obesity; obésité; perte de poids; restriction calorique; subclinical hypothyroidism; thyroid; thyroïde; weight loss.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Caloric Restriction / methods*
  • Diet, Reducing / methods
  • Fasting / physiology*
  • Female
  • Follow-Up Studies
  • Humans
  • Hypothyroidism / complications*
  • Male
  • Middle Aged
  • Obesity / complications*
  • Obesity / diet therapy*
  • Weight Loss / physiology*
  • Young Adult