Cortex-wide Computations in Complex Decision Making in Mice

Pankaj K Gupta; Timothy H Murphy

doi:10.1016/j.neuron.2019.10.043

Cortex-wide Computations in Complex Decision Making in Mice

Neuron. 2019 Nov 20;104(4):631-633. doi: 10.1016/j.neuron.2019.10.043.

Authors

Pankaj K Gupta¹, Timothy H Murphy²

Affiliations

¹ Department of Psychiatry, Kinsmen Laboratory of Neurological Research; University of British Columbia, Vancouver, BC V6T 1Z3, Canada; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
² Department of Psychiatry, Kinsmen Laboratory of Neurological Research; University of British Columbia, Vancouver, BC V6T 1Z3, Canada; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC V6T 1Z3, Canada. Electronic address: thmurphy@mail.ubc.ca.

PMID: 31751543
DOI: 10.1016/j.neuron.2019.10.043

Abstract

Seemingly, a paradox exists between reports of wide-scale task-dependent cortical activity and the causal requirement for only a restricted number of motor and sensory cortical areas in some behavioral studies. In this issue of Neuron, Pinto et al. (2019) indicate that scenarios where mice must accumulate evidence and hold it during a delay period are causally linked to wide regions of cortex.

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MeSH terms

Animals
Decision Making
Mice
Parietal Lobe
Visual Cortex*