A Niche for Plasma Cells: The Skin

Selda Karaaslan; Mary M Tomayko

doi:10.1016/j.jid.2019.06.133

A Niche for Plasma Cells: The Skin

J Invest Dermatol. 2019 Dec;139(12):2411-2414. doi: 10.1016/j.jid.2019.06.133.

Authors

Selda Karaaslan¹, Mary M Tomayko²

Affiliations

¹ Department of Dermatology, Yale University, New Haven, Connecticut, USA.
² Department of Dermatology, Yale University, New Haven, Connecticut, USA; Department of Pathology, Yale University, New Haven, Connecticut, USA. Electronic address: mary.tomayko@yale.edu.

PMID: 31753124
DOI: 10.1016/j.jid.2019.06.133

Abstract

Antibodies are key components of the skin immune barrier, and antibodies directed toward skin structures can result in disease. Wilson et al. (2019) show that healthy skin is a niche for antibody secreting plasma cells and plasmablasts, and that inflammation and immunization increase their numbers. This work advances our understanding of skin associated B and plasma cells in health and disease.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Humans
Immunization*
Immunoglobulin M
Inflammation
Plasma Cells*
Skin

Substances

Immunoglobulin M

Grants and funding

R01 AI122448/AI/NIAID NIH HHS/United States