Pulmonary veno-occlusive disease associated with severe reduction of single-breath carbon monoxide diffusing capacity

Respiration. 1988;53(4):262-6. doi: 10.1159/000195438.


A 49-year-old woman presented with pulmonary hypertension, profound arterial hypoxemia, and a single-breath carbon monoxide diffusing capacity (DLCO) which was 17% of predicted. History, physical examination, and chest roentgenograms did not suggest the presence of parenchymal pulmonary disease. Spirometry and lung volume measurements were within normal limits. Pulmonary veno-occlusive disease was diagnosed by lung biopsy. This case illustrates the severe reduction of DLCO which can be associated with pulmonary veno-occlusive disease.

Publication types

  • Case Reports

MeSH terms

  • Carbon Monoxide / analysis*
  • Female
  • Humans
  • Hypertension, Pulmonary / complications*
  • Lung / pathology
  • Middle Aged
  • Pulmonary Diffusing Capacity*
  • Pulmonary Veno-Occlusive Disease / pathology
  • Pulmonary Veno-Occlusive Disease / physiopathology*


  • Carbon Monoxide