Multitasking Actors of Staphylococcus aureus Metabolism and Virulence

Xin Tan; Mathieu Coureuil; Alain Charbit; Anne Jamet

doi:10.1016/j.tim.2019.10.013

Multitasking Actors of Staphylococcus aureus Metabolism and Virulence

Trends Microbiol. 2020 Jan;28(1):6-9. doi: 10.1016/j.tim.2019.10.013. Epub 2019 Nov 18.

Authors

Xin Tan¹, Mathieu Coureuil¹, Alain Charbit¹, Anne Jamet²

Affiliations

¹ Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, Paris 75006, France; INSERM U1151 - CNRS UMR 8253, Institut Necker-Enfants Malades. Equipe 7: Pathogénie des Infections Systémiques, Paris, France.
² Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, Paris 75006, France; INSERM U1151 - CNRS UMR 8253, Institut Necker-Enfants Malades. Equipe 7: Pathogénie des Infections Systémiques, Paris, France; Service de Microbiologie, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France. Electronic address: anne.jamet@inserm.fr.

PMID: 31753539
DOI: 10.1016/j.tim.2019.10.013

Abstract

Recent studies have uncovered the striking commonality of multitasking molecular actors linking metabolism and virulence regulation. Beyond the well known importance of carbohydrate and amino acid metabolism regulators in coordinating metabolic pathways and pathogenesis, we highlight recent major advances linking lipid and nucleic acid pathways to virulence regulation in Staphylococcus aureus.

Keywords: Staphylococcus aureus; metabolism; virulence.

MeSH terms

Amino Acids / metabolism
Animals
Biosynthetic Pathways
Carbohydrate Metabolism
Fatty Acids / metabolism
Humans
Metabolic Networks and Pathways
Staphylococcal Infections / microbiology*
Staphylococcus aureus / metabolism*
Staphylococcus aureus / pathogenicity*
Virulence

Substances

Amino Acids
Fatty Acids