Adolescent tuberculosis

Lancet Child Adolesc Health. 2020 Jan;4(1):68-79. doi: 10.1016/S2352-4642(19)30337-2. Epub 2019 Nov 18.


Adolescence is characterised by a substantial increase in the incidence of tuberculosis, a known fact since the early 20th century. Most of the world's adolescents live in low-income and middle-income countries where tuberculosis remains common, and where they comprise a quarter of the population. Despite this, adolescents have not yet been addressed as a distinct population in tuberculosis policy or within tuberculosis treatment services, and emerging evidence suggests that current models of care do not meet their needs. This Review discusses up-to-date information about tuberculosis in adolescence, with a focus on the management of infection and disease, including HIV co-infection and rifampicin-resistant tuberculosis. We outline the progress in vaccine development and highlight important directions for future research.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adolescent
  • Antitubercular Agents / therapeutic use
  • Child
  • Coinfection
  • Developing Countries / statistics & numerical data
  • HIV Infections / complications
  • Humans
  • Incidence
  • Tuberculosis / diagnosis
  • Tuberculosis / drug therapy*
  • Tuberculosis / epidemiology*
  • Tuberculosis / prevention & control
  • Tuberculosis Vaccines
  • Tuberculosis, Multidrug-Resistant / diagnosis
  • Tuberculosis, Multidrug-Resistant / drug therapy
  • Tuberculosis, Multidrug-Resistant / epidemiology
  • Tuberculosis, Multidrug-Resistant / prevention & control
  • Young Adult


  • Antitubercular Agents
  • Tuberculosis Vaccines