Na+/H+ ion-exchange property of postmortem human gastric mucus

Scand J Gastroenterol. 1988 Aug;23(6):701-4. doi: 10.3109/00365528809093936.


The Na+/H+ ion-exchange property of human gastric mucus and its relationship to age has been studied. Mucus was collected from 40 postmortem human stomachs (age range, 21-83 years) within 24 h of traumatic death. Twenty-one stomachs (age range, 21-76 years) were free of Campylobacter pylori infection and histologic gastritis. Mucus from these stomachs was consistently a cation exchanger at pH 6 in an in vitro system. The cation-exchange capacity of mucus from seven stomachs within the age range 55-70 years was 50% less than the cation-exchange capacity of mucus from eight stomachs within the age range 20-35 years. This study shows that human gastric mucus at pH 6 is a cation exchanger and that the ion-exchange capacity decreases with age.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Age Factors
  • Aged
  • Gastric Mucosa / physiology*
  • Humans
  • Hydrogen-Ion Concentration
  • In Vitro Techniques
  • Ion Exchange
  • Middle Aged
  • Sodium / physiology


  • Sodium