Successful Mesenchymal Stem Cell Application in Supraventricular Tachycardia-Related Necrotizing Enterocolitis: A Case Report

Fetal Pediatr Pathol. 2021 Jun;40(3):250-255. doi: 10.1080/15513815.2019.1693672. Epub 2019 Nov 22.


Necrotizing enterocolitis (NEC) is one of the most important life- threatening diseases in neonates. Recurrent episodes of supraventricular tachycardia (SVT) can lead to gut ischemia, with subsequent reperfusion injury resulting in NEC. Mesenchymal stem cells (MSCs) are multi-potential cells which can differentiate into multiple cell types. Case report: A 22-day old male baby delivered to 34 yr old mother at 37-weeks' gestation via cesarean section, birth weight 3550 g, developed NEC 14 hours after being treated with cardioversion for SVT. At laparotomy, there was pan-NEC, and 60 cm of necrotic and perforated bowel was resected. 1 × 107 umbilical cord origin allogeneic MSCs were given intravenously, with subsequent improvement of the remaining bowel. Conclusion: MSC may be a promising treatment for adjacent ischemic bowel in NEC helping prevent short bowel syndrome.

Keywords: Supraventricular tachycardia; mesenchymal stem cell; necrotizing enterocolitis; newborn.

Publication types

  • Case Reports

MeSH terms

  • Cesarean Section
  • Enterocolitis, Necrotizing* / etiology
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Intestinal Perforation*
  • Male
  • Mesenchymal Stem Cells*
  • Pregnancy
  • Tachycardia, Supraventricular* / etiology
  • Tachycardia, Supraventricular* / therapy