Preparation and application of dextran and its derivatives as carriers

Fang Chen; Gangliang Huang; Hualiang Huang

doi:10.1016/j.ijbiomac.2019.11.151

Preparation and application of dextran and its derivatives as carriers

Int J Biol Macromol. 2020 Feb 15:145:827-834. doi: 10.1016/j.ijbiomac.2019.11.151. Epub 2019 Nov 19.

Authors

Fang Chen¹, Gangliang Huang², Hualiang Huang³

Affiliations

¹ Active Carbohydrate Research Institute, Chongqing Key Laboratory of Inorganic Functional Materials, College of Chemistry, Chongqing Normal University, Chongqing 401331, China.
² Active Carbohydrate Research Institute, Chongqing Key Laboratory of Inorganic Functional Materials, College of Chemistry, Chongqing Normal University, Chongqing 401331, China. Electronic address: huangdoctor226@163.com.
³ School of Chemistry and Environmental Engineering, Wuhan Institute of Technology, Wuhan, 430073, China.

PMID: 31756474
DOI: 10.1016/j.ijbiomac.2019.11.151

Abstract

As a natural and renewable biological macromolecule, dextran not only has excellent biodegradability, but also has good biocompatibility. Dextran and its derivatives are functional polymers for the construction of targeted drug delivery systems. Herein, the application of dextran as prodrug and nanoparticle/nanogel/microsphere/micelle carrier for targeting drug delivery system was summarized. It is clarified that dextran is an important biomaterial with application value.

Keywords: Dextran; Nanocarrier; Targeted drug delivery.

Publication types

Review

MeSH terms

Animals
Biocompatible Materials / chemistry
Dextrans / chemistry*
Drug Carriers / chemistry*
Drug Delivery Systems / methods
Humans
Micelles
Microspheres
Nanoparticles / chemistry

Substances

Biocompatible Materials
Dextrans
Drug Carriers
Micelles