Andrographolide, a Natural Antioxidant: An Update

Antioxidants (Basel). 2019 Nov 20;8(12):571. doi: 10.3390/antiox8120571.


Traditionally, Andrographis paniculata has been used as an herbal remedy for lung infection treatments. Its leaves contain a diterpenoid labdane called andrographolide responsible for a wide range of biological activities such as antioxidant, anti-inflammatory, and anti-cancer properties. This manuscript is a brief review of the antioxidant mechanisms and the regulation of the Nrf2 (nuclear factor (erythroid-derived 2)-like 2) signaling pathway by andrographolide.

Keywords: Andrographis paniculata; Nrf2; andrographolide; oxidative stress.

Publication types

  • Review