Michael Addition Reaction Catalyzed by Imidazolium Chloride to Protect Amino Groups and Construct Medium Ring Heterocycles

Molecules. 2019 Nov 20;24(23):4224. doi: 10.3390/molecules24234224.

Abstract

An effective approach for amino protection and construction of a seven-membered ring has been developed. The method uses imidazolium chloride to carry out the Michael addition reaction at low temperatures and perform amino deprotection or construction of a seven-membered ring at high temperatures.

Keywords: Michael addition reaction; amino deprotection; amino protection; imidazolium chloride; seven-membered ring; solvent-free.

MeSH terms

  • Heterocyclic Compounds* / chemical synthesis
  • Heterocyclic Compounds* / chemistry
  • Imidazoles / chemistry*

Substances

  • Heterocyclic Compounds
  • Imidazoles
  • imidazole