Personalized Medicine in Gynecologic Cancer: Fact or Fiction?

Surg Oncol Clin N Am. 2020 Jan;29(1):105-113. doi: 10.1016/j.soc.2019.08.008.


Personalized medicine in gynecologic oncology is an evolving field. In recent years, tumor profiling and large databases such as TCGA and NCI-Match have provided us with enormous amounts of molecular data. Several therapies that capitalize on novel genetic and immune discoveries including VEGF inhibitors, PARP inhibitors, and cancer vaccinations are discussed in this article. Additionally, we have seen direct to consumer marketing play an important role in cancer care and prevention as patients have increased ability to access genetic testing. This presents a unique challenge to gynecologic oncology providers as we learn to navigate the world of personalized medicine.

Keywords: Gynecologic malignancies; Personalized medicine; Precision medicine; Targeted therapies.

Publication types

  • Review

MeSH terms

  • Antineoplastic Agents / therapeutic use*
  • Biomarkers, Tumor / genetics*
  • Female
  • Genital Neoplasms, Female / drug therapy*
  • Genital Neoplasms, Female / genetics
  • Humans
  • Molecular Targeted Therapy / methods*
  • Pharmacogenetics / methods*
  • Precision Medicine / methods
  • Precision Medicine / trends*


  • Antineoplastic Agents
  • Biomarkers, Tumor