Precision Medicine in Colorectal Surgery

Sangeetha Prabhakaran; Joseph Leong; Nicholas J Petrelli; Vijay P Khatri

doi:10.1016/j.soc.2019.09.001

Precision Medicine in Colorectal Surgery

Surg Oncol Clin N Am. 2020 Jan;29(1):23-34. doi: 10.1016/j.soc.2019.09.001.

Authors

Sangeetha Prabhakaran¹, Joseph Leong², Nicholas J Petrelli³, Vijay P Khatri⁴

Affiliations

¹ Division of Surgical Oncology, Department of Surgery, University of New Mexico, Albuquerque, NM, USA.
² Department of Surgery, California Northstate University College of Medicine, Elk Grove, CA 95757, USA.
³ Department of Surgery, Helen F. Graham Cancer Center & Research Institute, Christiana Care Health System, Newark, DE, USA; Department of Surgery, Thomas Jefferson University, Philadelphia, PA, USA.
⁴ Department of Surgery, California Northstate University College of Medicine, Elk Grove, CA 95757, USA. Electronic address: vijay.khatri@cnsu.edu.

PMID: 31757311
DOI: 10.1016/j.soc.2019.09.001

Abstract

This article reviews advances in precision medicine for colorectal carcinoma that have influenced screening and treatment, and potentially prevention. Advances in molecular techniques have made it possible for better patient selection for therapies; therefore, mutational analysis should be performed at diagnosis to guide treatment. Future efforts should focus on validating these treatments in specific subgroups and on understanding the mechanisms of resistance to therapies to enable treatment optimization, promote efficacy, and reduce treatment costs and toxicities.

Keywords: Colorectal surgery; Precision medicine; Predictive biomarkers.

Publication types

Review

MeSH terms

Colorectal Surgery / standards*
Genomics / methods*
Humans
Neoplasms / pathology
Neoplasms / surgery*
Patient Selection*
Precision Medicine / methods
Precision Medicine / trends*