8p deletions in renal cell carcinoma are associated with unfavorable tumor features and poor overall survival

Urol Oncol. 2020 Feb;38(2):43.e13-43.e20. doi: 10.1016/j.urolonc.2019.09.024. Epub 2019 Nov 19.

Abstract

Background and methods: 8p deletions are common in renal cell carcinoma. To study their prognostic impact and association with kidney cancer phenotype, a tissue microarray with 1,809 cancers was analyzed by fluorescence in situ hybridization for 8p21 copy numbers.

Results: One thousand four hundred and seventy four interpretable tumors showed substantial differences between renal cancer subtypes. That 8p deletion was only seen in 1 (0.5%) of 216 papillary carcinomas underscores the biologic uniqueness of papillary kidney cancer, which is also defined by a highly distinct morphology. 8p deletions were found in 13.2% of 976 clear cell carcinomas, 7.8% of 77 chromophobe carcinomas, 0.8% of 119 oncocytomas, but also in several rare tumor entities including 1 of 4 collecting duct cancers, 1 of 3 multilocular cystic clear cell renal cell neoplasm of low malignancy, 2 of 10 Xp11.2 translocation cancers, 3 of 18 not otherwise specified carcinomas, and 1 analyzed medullary carcinoma. In clear cell carcinomas, 8p deletions were significantly associated with higher International Society of Urologic Pathologists (ISUP) grading (P = 0.0014), Fuhrman (P = 0.0003) and Thoenes grade (P = 0.0033), advanced tumor stage (P = 0.0002), large tumor diameter (P = 0.0019), distant metastases (P = 0.0183), overall survival (P = 0.0394), and recurrence free survival (P < 0.0001). In multivariate analysis, the prognostic role of 8p deletions was not independent of established clinic-pathological parameters. In conclusion, 8p deletions are strongly linked to tumor aggressiveness in clear cell kidney cancer.

Conclusions: Because 8p deletions are easy to measure by fluorescence in situ hybridization, 8p deletion assessment, most likely in combination with other parameters, may have a role in future prognosis assessment in clear cell kidney cancer.

Keywords: 8p21 deletion; Fluorescence in situ hybridization; Prognosis; Renal cell cancer; Tissue microarray.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Carcinoma, Renal Cell / genetics*
  • Carcinoma, Renal Cell / mortality
  • Chromosome Deletion
  • Chromosomes, Human, Pair 8 / genetics
  • Female
  • Humans
  • In Situ Hybridization, Fluorescence / methods*
  • Kidney Neoplasms / genetics*
  • Kidney Neoplasms / mortality
  • Male
  • Middle Aged
  • Survival Analysis

Supplementary concepts

  • Chromosome 8, monosomy 8p