A research framework for cognitive aging and Alzheimer's disease among diverse US Latinos: Design and implementation of the Hispanic Community Health Study/Study of Latinos-Investigation of Neurocognitive Aging (SOL-INCA)

Alzheimers Dement. 2019 Dec;15(12):1624-1632. doi: 10.1016/j.jalz.2019.08.192. Epub 2019 Nov 20.


Hispanics/Latinos are the largest ethnic/racial group in the United States and at high risk for Alzheimer's disease and related dementia (ADRD). Yet, ADRD among diverse Latinos is poorly understood and disparately understudied or unstudied compared to other ethnic/racial groups that leave the nation ill-prepared for major demographic shifts that lay ahead in coming decades. The primary purpose of this Perspectives article was to provide a new research framework for advancing Latino ADRD knowledge, encompassing the unique sociocultural, cardiometabolic, and genomic aspects of Latino health, aging, and ADRD. In addition, we describe some of the research challenges to progress in Latino ADRD research. Finally, we present the Study of Latinos - Investigation of Neurocognitive Aging (SOL-INCA) as an example of implementing this new framework for advancing Latino ADRD research.

Keywords: Cognitive function; Epidemiology; Hispanic/Latinos; Hispanics; Latinos; Neurocognitive function; Neuroepidemiology; Neuropsychology; Population neuroscience.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Alzheimer Disease / epidemiology*
  • Alzheimer Disease / genetics
  • Cognitive Aging*
  • Cognitive Dysfunction / epidemiology
  • Cognitive Dysfunction / genetics
  • Health Services Research*
  • Hispanic or Latino / statistics & numerical data*
  • Humans
  • Middle Aged
  • Neuropsychological Tests
  • Public Health / statistics & numerical data*
  • United States / epidemiology