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. 2019 Dec 27;82(12):3482-3488.
doi: 10.1021/acs.jnatprod.9b00675. Epub 2019 Nov 25.

Trikoramide A, a Prenylated Cyanobactin from the Marine Cyanobacterium Symploca hydnoides

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Trikoramide A, a Prenylated Cyanobactin from the Marine Cyanobacterium Symploca hydnoides

Ma Yadanar Phyo et al. J Nat Prod. .

Abstract

A new cyclic decapeptide, trikoramide A (1), has been isolated from samples of the marine cyanobacterium Symploca hydnoides, collected from Bintan Island, Indonesia. Trikoramide A (1) is a C-prenylated cyclotryptophan-containing cyanobactin. Its planar structure was deduced by 1D and 2D NMR spectroscopy as well as HR-MS/MS data. In addition, its absolute configuration was determined by Marfey's method and 2D NOESY NMR spectroscopic analysis. Compound 1 possessed cytotoxicity against the MOLT-4 and AML2 cancer cell lines with IC50 values of 4.8 and 8.2 μM, respectively.

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