Estimation of associations between 10 common gene polymorphisms and gastric cancer: evidence from a meta-analysis

J Clin Pathol. 2020 Jun;73(6):318-321. doi: 10.1136/jclinpath-2019-206189. Epub 2019 Nov 25.

Abstract

Aims: Associations between polymorphisms in cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4)/mannose-binding lectin (MBL)/interleukin-4 (IL-4)/interleukin-6 (IL-6)/phospholipase C ε-1 (PLCE1) and gastric cancer (GC) were already reported by many studies, yet the conclusions of these studies were somehow controversial. The aim of this meta-analysis was to better clarify associations between polymorphisms in CTLA-4/MBL/IL-4/IL-6/PLCE1 and GC by combing the results of all relevant studies.

Methods: Eligible studies were searched from PubMed, Embase, WOS and CNKI. We used Review Manager to combine the results of individual studies.

Results: Forty-three studies were included in this meta-analysis. Combined results revealed that CTLA-4 rs5742909 (dominant comparison: OR: 1.58, 95 % CI: 1.01 to 2.48; allele comparison: OR: 1.69, 95 % CI: 1.12 to 2.56) and PLCE1 rs2274223 (dominant comparison: OR: 0.84, 95 % CI: 0.72 to 0.98; recessive comparison: OR: 1.23, 95 % CI: 1.08 to 1.40; over-dominant comparison: OR: 1.16, 95 % CI: 1.00 to 1.34; allele comparison: OR 0.88, 95 % CI 0.78 to 0.99) polymorphisms were significantly associated with GC in the general population. We also obtained similar significant associations with GC for rs5742909 and rs2274223 polymorphisms in East Asians. Nevertheless, no positive results were observed for the other eight investigated polymorphisms.

Conclusion: Collectively, this meta-analysis demonstrated that CTLA-4 rs5742909 and PLCE1 rs2274223 polymorphisms may confer susceptibility to GC, especially for East Asians.

Keywords: CTLA-4, Cytotoxic T-lymphocyte-associated antigen 4; GC, Gastric cancer; IL-4, Interleukin-4; IL-6, Interleukin-6; MBL, Mannose binding lectin; PLCE1, Phospholipase C ε-1; meta-analysis.

Publication types

  • Meta-Analysis

MeSH terms

  • CTLA-4 Antigen / genetics*
  • Genetic Predisposition to Disease
  • Humans
  • Interleukin-4 / genetics
  • Interleukin-6 / genetics
  • Mannose-Binding Lectin / genetics*
  • Phosphoinositide Phospholipase C / genetics*
  • Polymorphism, Genetic / genetics*
  • Stomach Neoplasms / genetics*

Substances

  • CTLA-4 Antigen
  • CTLA4 protein, human
  • IL4 protein, human
  • IL6 protein, human
  • Interleukin-6
  • MBL2 protein, human
  • Mannose-Binding Lectin
  • Interleukin-4
  • Phosphoinositide Phospholipase C
  • phospholipase C epsilon