Echocardiographic predictors of acute kidney injury in neonates with a patent ductus arteriosus

J Perinatol. 2020 Mar;40(3):510-514. doi: 10.1038/s41372-019-0560-1. Epub 2019 Nov 25.


Objective: To investigate acute kidney injury (AKI) in neonates with a patent ductus arteriosus (PDA) including incidence, risk factors, and possible correlations between PDA-related echocardiographic measurements and AKI incidence.

Study design: We conducted a single-center retrospective cohort study of infants admitted to the neonatal intensive care unit with a diagnosis of a PDA between July 2015 and July 2017. Infants were evaluated for development of AKI based on the KDIGO criteria and a multivariable logistic regression analysis was performed.

Results: A total of 142 neonates with moderate or large PDAs were included, 43 (30%) developed AKI. Patients who developed AKI had longer length of stay, lower birth weights, lengths, and gestational ages. No echocardiographic measurements were predictive of an increased risk for developing AKI.

Conclusion: There are no significant differences in commonly measured echocardiographic markers of PDA hemodynamic significance in neonates who develop AKI.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Acute Kidney Injury / etiology*
  • Birth Weight
  • Ductus Arteriosus, Patent / complications*
  • Ductus Arteriosus, Patent / diagnostic imaging
  • Ductus Arteriosus, Patent / drug therapy
  • Echocardiography*
  • Female
  • Gestational Age
  • Heart / diagnostic imaging
  • Humans
  • Infant, Newborn
  • Length of Stay
  • Logistic Models
  • Male
  • Predictive Value of Tests
  • Retrospective Studies
  • Risk Factors