Upfront Therapies and Downstream Effects: Navigating Late Effects in Childhood Cancer Survivors in the Current Era

Curr Oncol Rep. 2019 Nov 25;21(12):104. doi: 10.1007/s11912-019-0861-8.


Purpose of review: As survival rates of those diagnosed with childhood cancer improve over time, the number of long-term survivors continues to grow. Advances have not only been made in the upfront treatment of childhood cancer, but also in the identification and treatment of late complications that may arise as a result of the chemotherapy, radiotherapy, or surgical interventions required to provide a cure.

Recent findings: As new therapies emerge that are often more targeted to cancerous cells while sparing healthy tissues, the hope is that cure can be achieved without the same long-term side effects for survivors. However, much is unknown regarding how these novel interventions will impact patients in the years to come. It is critical that we continue to follow patients treated with new modalities in order to identify and treat the long-term complications that may arise in future childhood cancer survivors.

Keywords: Childhood cancer; Late effects; Long-term complications; Novel therapy; Survivorship.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Cancer Survivors / statistics & numerical data*
  • Cardiovascular Diseases / etiology
  • Cardiovascular Diseases / therapy*
  • Child
  • Cognition Disorders / etiology
  • Cognition Disorders / therapy*
  • Disease Progression
  • Endocrine System Diseases / etiology
  • Endocrine System Diseases / therapy*
  • Humans
  • Neoplasms / complications*
  • Neoplasms / therapy
  • Risk Factors
  • Survival Rate