Clevidipine-Induced Extreme Hypoxemia in a Neurosurgical Patient: A Case Report

A A Pract. 2020 Jan 15;14(2):60-62. doi: 10.1213/XAA.0000000000001146.


Clevidipine-induced pulmonary shunting is a little-reported adverse effect, manifesting as refractory hypoxemia, which may cause significant patient harm. We present the case of a mechanically ventilated patient admitted to the intensive care unit following a neurosurgical procedure. He was treated postoperatively with clevidipine for blood pressure management, and within 16 hours, he developed profound refractory hypoxemia, requiring increased ventilatory support. A workup for other causes was negative. The hypoxemia recovered within 1 hour of clevidipine discontinuation. Though other calcium channel blockers have been reported to cause pulmonary shunting from vasodilation, this is a novel case report for clevidipine-induced hypoxemia.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Humans
  • Hypertension / drug therapy
  • Hypoxia / chemically induced*
  • Male
  • Neurosurgical Procedures / adverse effects*
  • Pyridines / adverse effects*
  • Respiration, Artificial


  • Pyridines
  • clevidipine