A dermatoglyphic study of a group of Sicilian children with fragile-X syndrome

Am J Med Genet. 1988 May-Jun;30(1-2):177-83. doi: 10.1002/ajmg.1320300116.


In a dermatoglyphic study of 14 fra(X) boys (compared with a control group of 191 normal schoolboys), we observed the following statistically significant (p less than 0.01) differences: 1) lower frequency of ulnar loops on the fingertips, particularly on the 2nd and 3rd fingers, with a corresponding increase of whorls; 2) transverse course of main line A; 3) increased frequency of abnormal palmar creases. The log score index of Simpson et al [1984] identified 71.4% of our patients and that of Rodewald et al [1986] 64.2%. The different values of these indexes can probably be attributed to ethnic differences. We think that by combining the results of dermatoglyphic analysis from several centers a more discriminatory log score index can be obtained.

MeSH terms

  • Child
  • Dermatoglyphics*
  • Fragile X Syndrome / diagnosis*
  • Fragile X Syndrome / pathology
  • Humans
  • Male
  • Sex Chromosome Aberrations / diagnosis*