Citrus species: A Review of Traditional Uses, Phytochemistry and Pharmacology

Curr Pharm Des. 2020;26(1):44-97. doi: 10.2174/1381612825666191127115601.


The Citrus species from family Rutaceae has worldwide applications such as cardiovascular and gastrointestinal problems. Phytochemical investigations have shown that these plants have constituents including flavonoids, limonoids and carotenoids. There are many reports on a wide range of activities such as antiinflammatory, anti-oxidant, immunomodulatory, metabolic, cardiovascular and neuroprotective effects. In the current review, we discuss information regarding botany, phytochemistry, ethnobotany uses, traditional knowledge and pharmacological aspects of the Citrus species.

Keywords: Citrus spp. Rutaceae; immunomodulatory; pharmacological aspects; phytochemistry; traditional..

Publication types

  • Review

MeSH terms

  • Citrus / chemistry*
  • Ethnobotany
  • Ethnopharmacology
  • Phytochemicals / pharmacology*
  • Phytotherapy*
  • Plant Extracts / pharmacology


  • Phytochemicals
  • Plant Extracts