Vibrio cholerae at the Intersection of Immunity and the Microbiome

mSphere. 2019 Nov 27;4(6):e00597-19. doi: 10.1128/mSphere.00597-19.


Vibrio cholerae is a noninvasive pathogen that colonizes the small intestine and produces cholera toxin, causing severe secretory diarrhea. Cholera results in long lasting immunity, and recent studies have improved our understanding of the antigenic repertoire of V. cholerae Interactions between the host, V. cholerae, and the intestinal microbiome are now recognized as factors which impact susceptibility to cholera and the ability to mount a successful immune response to vaccination. Here, we review recent data and corresponding models to describe immune responses to V. cholerae infection and explain how the host microbiome may impact the pathogenesis of V. cholerae In the ongoing battle against cholera, the intestinal microbiome represents a frontier for new approaches to intervention and prevention.

Keywords: Vibrio cholerae; cholera; immune response; innate immunity; microbiome; vaccine.

Publication types

  • Review

MeSH terms

  • Animals
  • Cholera / immunology
  • Cholera / microbiology
  • Disease Models, Animal
  • Gastrointestinal Microbiome*
  • Host-Pathogen Interactions*
  • Humans
  • Immunity, Innate*
  • Microbial Interactions*
  • Vibrio cholerae / growth & development*
  • Vibrio cholerae / immunology*