Preventive and Therapeutic Effect of Ganoderma (Lingzhi) on Liver Injury

Adv Exp Med Biol. 2019;1182:217-242. doi: 10.1007/978-981-32-9421-9_9.


Ganoderma lucidum (G. lucidum, Lingzhi) has a wide range of hepatoprotective effects. Its bioactive substances include triterpenoids, polysaccharides, sterols, steroids, peptides, and other bioactive ingredients. Based on our research and other references, this chapter discusses the hepatoprotective effects of G. lucidum in different liver diseases, including hepatocellular carcinoma, nonalcoholic liver disease, alcoholic liver disease, hepatitis B, inflammation, fibrosis, and toxicant-induced liver injury. The liver protective mechanisms of G. lucidum vary from diseases to diseases. This chapter will summarize the hepatoprotective effects of G. lucidum on different liver injury and their clinical applications.

Keywords: Ganoderma; Lingzhi; Liver injury; Polysaccharides; Triterpenes.

Publication types

  • Review

MeSH terms

  • Biological Products / pharmacology*
  • Humans
  • Liver / drug effects*
  • Liver Diseases / drug therapy*
  • Reishi / chemistry*


  • Biological Products