Endoscopic Resection of Sinonasal Inverted Papilloma: A Multivariate Retrospective Analysis of Factors Affecting Recurrence and Persistence

Ear Nose Throat J. 2021 Sep;100(5_suppl):542S-548S. doi: 10.1177/0145561319890454. Epub 2019 Nov 28.


Sinonasal inverted papilloma (IP) is the most common benign epithelial tumor in the nasal cavity and paranasal sinuses, with a worldwide incidence between 0.6 and 1.5/100 000 persons per year. However, only a few studies have investigated patient-dependent factors related to IP recurrence and persistence. According to available evidence, these factors are still debated, and results are contradictory. In this multicenter retrospective study, we analyzed the clinical records of 130 patients who were surgically treated for sinonasal IP to evaluate the factors affecting recurrence and persistence of IP and compared the curative rates of different surgical approaches. Our analysis showed that IP recurrence is strongly related to specific risk factors including incomplete surgical removal, stage of disease, site of the lesion, surgical technique, and malignancy rate. In conclusion, the recurrence of IP may be affected by several risk factors; these factors must be carefully considered during clinical evaluation and especially during the follow-up of patients with IP.

Keywords: nasal cavity; persistence; recurrence; risk factors; sinonasal inverted papilloma.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Endoscopic Mucosal Resection*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Nasal Cavity / pathology
  • Nasal Cavity / surgery
  • Nasal Mucosa / pathology
  • Nasal Mucosa / surgery
  • Neoplasm Recurrence, Local / etiology*
  • Nose Neoplasms / pathology*
  • Nose Neoplasms / surgery
  • Papilloma, Inverted / pathology*
  • Papilloma, Inverted / surgery
  • Paranasal Sinus Neoplasms / pathology*
  • Paranasal Sinus Neoplasms / surgery
  • Retrospective Studies
  • Risk Factors
  • Treatment Outcome
  • Young Adult