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. Sep-Oct 2019;94(5):561-566.
doi: 10.1016/j.abd.2019.09.016. Epub 2019 Sep 30.

Rubeosis Faciei Diabeticorum Is Not Associated With Oxidative Stress and Skin Autofluorescence

Free PMC article

Rubeosis Faciei Diabeticorum Is Not Associated With Oxidative Stress and Skin Autofluorescence

Aleksejs Zavorins et al. An Bras Dermatol. .
Free PMC article


Background: Rubeosis faciei diabeticorum is a persistent facial erythema in patients with diabetes mellitus. The actual pathogenesis has not been studied. However, it is speculated to be a cutaneous diabetic microangiopathy.

Objective: Examine the correlation between the severity of facial erythema and the possible causes of microvascular diabetic complications, namely oxidative stress, hyperglycemia, and cutaneous accumulation of advanced glycation end-products .

Methods: Patients diagnosed with Type 2 diabetes mellitus (n=32) were enrolled in the study. The facial erythema index was measured using the Mexameter MX18; cutaneous accumulation of advanced glycation end-products was estimated by measuring skin auto fluorescence with the AGE Reader (DiagnOptics Technologies B.V. - Groningen, Netherlands). Glycated haemoglobin, total antioxidant status, and malondialdehyde were measured in blood by TBARS assay. The correlation between the selected variables was assessed by Spearman's rank test; p≤0.05 was considered statistically significant.

Results: There was a statistically significant correlation between total antioxidant status and the facial erythema index (ρ=0.398, p=0.024). Malondialdehyde, skin autofluorescence, glycated haemoglobin, body mass index, duration of diabetes, and age did not demonstrate statistically significant correlation with the facial erythema index.

Study limitations: This is an observational study. Elevation of total antioxidant status could have been caused by several factors that might have also influenced the development of rubeosis faciei, including hyperbilirubinemia and hyperuricemia.

Conclusions: The results contradicted expectations. Total antioxidant status correlated positively with facial erythema index; however, there was no correlation with oxidative stress and skin autofluorescence. Further investigations should be conducted to reveal the cause of total antioxidant status elevation in patients with rubeosis faciei.

Keywords: Diabetic angiopathies; Erythema; Face; Glycation end products, advanced; Oxidative stress; Skin manifestations.


Figure 1
Figure 1
There was a statistically significant correlation between total antioxidant stress (TAS) and the facial erythema index (ρ = 0.398, p = 0.024). AEU, arbitrary erythema units.

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    1. Thomas C.C., Philipson L.H. Update on diabetes classification. Med Clin North Am. 2015;99:1–16. - PubMed
    1. IDF Diabetes Atlas Brussels. 8th ed. Belgium: International Diabetes Federation; 2017. Available from: [cited 11.11.18].
    1. Yau J.W., Rogers S.L., Kawasaki R., Lamoureux E.L., Kowalski J.W., Bek T. Global prevalence and major risk factors of diabetic retinopathy. Diabetes Care. 2012;35:556–564. - PMC - PubMed
    1. Moura Neto A., Zantut-Wittmann D.E., Fernandes T.D., Nery M., Parisi M.C. Risk factors for ulceration and amputation in diabetic foot: study in a cohort of 496 patients. Endocrine. 2013;44:119–124. - PubMed
    1. Nasri H., Rafieian-Kopaei M. Diabetes mellitus and renal failure: prevention and management. J Res Med Sci. 2015;20:1112–1120. - PMC - PubMed

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