MYMD-1, a novel alkaloid compound, ameliorates the course of experimental autoimmune encephalomyelitis

Justin D Glenn; Itzy Morales Pantoja; Patrizio Caturegli; Katharine A Whartenby

doi:10.1016/j.jneuroim.2019.577115

MYMD-1, a novel alkaloid compound, ameliorates the course of experimental autoimmune encephalomyelitis

J Neuroimmunol. 2020 Feb 15:339:577115. doi: 10.1016/j.jneuroim.2019.577115. Epub 2019 Nov 20.

Authors

Justin D Glenn¹, Itzy Morales Pantoja², Patrizio Caturegli³, Katharine A Whartenby⁴

Affiliations

¹ Depts of Neurology, Johns Hopkins University School of Medicine, USA.
² Depts of Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, USA.
³ Depts of Pathology, Johns Hopkins University School of Medicine, USA.
⁴ Depts of Neurology, Johns Hopkins University School of Medicine, USA; Depts of Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, USA; Depts of Oncology, Johns Hopkins University School of Medicine, USA. Electronic address: whartenby@jhmi.edu.

PMID: 31778849
DOI: 10.1016/j.jneuroim.2019.577115

Abstract

Multiple sclerosis (MS) is an autoimmune disease that remains in need of effective therapies. Plant-derived medicines have appealing properties for the treatment of autoimmune diseases. MYMD-1 is a synthetic plant alkaloid that has been shown to ameliorate the course of autoimmune thyroiditis. The goal of the present study was to determine whether MYMD-1 would produce similar beneficial effects in a mouse model of MS, experimental autoimmune encephalomyelitis (EAE) induced by immunization with myelin oligodendrocyte glycoprotein. MYMD-1 improved the course of EAE and suppressed activation of effector T cells without causing global immunosuppression or toxicity. These results suggest that MYMD-1 may be of interest for evaluating for the treatment of autoimmune diseases.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkaloids / chemical synthesis
Alkaloids / pharmacology
Alkaloids / therapeutic use*
Animals
Cells, Cultured
Dose-Response Relationship, Drug
Encephalomyelitis, Autoimmune, Experimental / drug therapy*
Encephalomyelitis, Autoimmune, Experimental / immunology*
Encephalomyelitis, Autoimmune, Experimental / metabolism
Female
Mice
Mice, Inbred C57BL
T-Lymphocytes / drug effects
T-Lymphocytes / immunology
T-Lymphocytes / metabolism

Substances

Alkaloids