ASK1 inhibition triggers platelet apoptosis via p38-MAPK-mediated mitochondrial dysfunction

Haematologica. 2020 Aug;105(8):e419-e423. doi: 10.3324/haematol.2019.233908. Epub 2019 Nov 28.

Authors

Kurnegala Manikanta¹, Somanathapura K Naveen Kumar¹, Mahadevappa Hemshekhar¹, Kempaiah Kemparaju², Kesturu S Girish^{2

3}

Affiliations

¹ Department of Studies in Biochemistry, University of Mysore, Manasagangotri, Mysuru.
² Department of Studies in Biochemistry, University of Mysore, Manasagangotri, Mysuru ksgbaboo@gmail.com kemparajuom@gmail.com.
³ Department of Studies and Research in Biochemistry, Tumkur University, Tumakuru, India.

No abstract available

Publication types

Letter

MeSH terms

Animals
Apoptosis*
Blood Platelets*
MAP Kinase Kinase Kinase 5*
Mice
Mitochondria / pathology*
Reactive Oxygen Species
p38 Mitogen-Activated Protein Kinases*

Substances

Reactive Oxygen Species
p38 Mitogen-Activated Protein Kinases
MAP Kinase Kinase Kinase 5
Map3k5 protein, mouse