Introduction: The increasing knowledge of adropin, afamin, and neudesin and the regulation of glucose metabolism and insulin resistance allows for the assessment of the differences in their concentrations between the groups with varied duration of diabetes mellitus (DM).
Aim of the study: Assessment of serum levels of adropin, afamin, and neudesin in children with type 1 diabetes, with respect to the disease duration.
Materials and methods: The study consisted of 138 patients aged 5-18 years (M 40.58%). Children with type 1 diabetes (n = 68) were compared to the control group (n = 70). The diabetic group was divided into 4 subgroups: (I) newly diagnosed patients, after an episode of ketoacidosis (n = 14), (II) duration no longer than 5 years (n = 18), (III) 5 to 10 years (n = 27), and (IV) longer than 10 years (n = 9). Serum concentrations of adropin, afamin, and neudesin were assessed and compared between the groups of patients. The criterion for statistical significance was p < 0.05.
Results: The concentrations of adropin and afamin across all subgroups were lower than that in the control group, while neudesin levels were higher in diabetic patients compared to the control group. The differences were statistically significant.
Conclusions: Adropin, afamin, and neudesin may play a major role in the regulation of glucose metabolism and have a significant potential as novel biomarkers to predict future metabolic disorders. However, further multicentre studies on a larger cohort of patients are necessary to specify the role of these substances in the course and treatment of type 1 diabetes.
Copyright © 2019 Agnieszka Polkowska et al.
Conflict of interest statement
The authors declare that there are no conflicts of interest regarding the publication of this paper.
Afamin and Adropin in Patients With Alcohol-Induced Liver CirrhosisA Prystupa et al. Ann Agric Environ Med 25 (3), 527-531. PMID 30260179.The aim of the study was to determine serum concentrations of afamin and adropin in patients with alcoholic liver cirrhosis and to define their correlation with the stage …
Is Afamin a Novel Biomarker for Gestational Diabetes Mellitus? A Pilot StudyA Köninger et al. Reprod Biol Endocrinol 16 (1), 30. PMID 29587878.Afamin may serve as a new early biomarker for pathological glucose metabolism during pregnancy. Further research is needed to determine afamin's concentrations during pre …
Assessment of Serum Concentrations of Ghrelin, Obestatin, Omentin-1, and Apelin in Children With Type 1 DiabetesA Polkowska et al. Biomed Res Int 2016, 8379294. PMID 26904686.The increasing knowledge on the functions of gastric peptides and adipokines in the body allows the assumption of their major role linking the process of food intake, nut …
Serum Content of Total Adipionectin in the ChNPP Accident Clean Up Workers of the «iodine Period» Suffering From Type 2 Diabetes Mellitus (Literature Review and Research Data)NS Dombrovska et al. Probl Radiac Med Radiobiol 22, 353-371. PMID 29286520. - ReviewSerum concentration of total adiponectin in the Chornobyl NPP ACUW of the iodine peri od and suffering type 2 DM despite having normal body weight or overweight or any de …
FreeStyle Libre Flash Glucose Self-Monitoring System: A Single-Technology Assessment [Internet]J Bidonde et al. PMID 29553668. - ReviewOverall, the evidence for the intervention of interest was limited but suggests that FreeStyle Libre increases treatment satisfaction, reduces some hypo- and hyperglycaem …