Long-term remission of disseminated parathyroid cancer following immunotherapy

Endocrine. 2020 Jan;67(1):204-208. doi: 10.1007/s12020-019-02136-z. Epub 2019 Nov 28.


Purpose: Parathyroid cancer is a rare tumor associated with poor prognosis particularly when disseminated. While chemotherapy and/or radiotherapy are of no clinical value in disseminated disease, immunotherapy should be considered.

Subject and results: A patient with CDC73-associated metastatic parathyroid carcinoma was treated with combined anti-hPTH immunotherapy and surgery.

Conclusions: Following five courses of anti-hPTH immunotherapy and subsequent surgery, a 12-year long remission of disseminated parathyroid cancer is reported. This case further supports the ever-expanding spectrum of cancers that may benefit from immunotherapy.

Keywords: Cancer; Immunotherapy; Parathyroid.

Publication types

  • Research Support, Non-U.S. Gov't