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, 9 (1), 17913

Left Ventricular Deformation in Patients With Connective Tissue Disease: Evaluated by 3.0T Cardiac Magnetic Resonance Tissue Tracking

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Left Ventricular Deformation in Patients With Connective Tissue Disease: Evaluated by 3.0T Cardiac Magnetic Resonance Tissue Tracking

Jin Wang et al. Sci Rep.

Abstract

The aim of this study was to assess left ventricular (LV) myocardial strain in patients with connective tissue disease (CTD) and compare LV deformation between subgroups of idiopathic inflammatory myopathy (IIM) and non-IIM. Ninety-eight patients with CTD, comprising 56 with IIM and 42 with non-IIM, and 30 healthy subjects were enrolled and underwent 3.0T cardiac magnetic resonance imaging (MRI) scanning. The LV function and strain parameters were measured and assessed. Our result revealed that CTD patients had preserved LV ejection fraction (60.85%) and had significantly decreased global and regional peak strain (PS) in radial, circumferential, and longitudinal directions (all p < 0.05). IIM patients showed significantly reduced global longitudinal PS (GLPS) and longitudinal PS at apical slice, whereas all strain parameters decreased in non-IIM patients. Except GLPS and longitudinal PS at apical slice, all strain parameters in non-IIM patients were lower than those in IIM patients. By Pearson's correlation analysis, the LV global radial and circumferential PS were correlated to N-terminal pro-brain natriuretic peptide level and LV ejection fraction in both IIM and non-IIM patients. This study indicated that CTD patients showed abnormal LV deformation despite with preserved LVEF. The impairment of LV deformation differed between IIM and non-IIM patients.

Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Pearson’s correlation analysis of Nt-proBNP with GRPS, GCPS, and GLPS in the non-IIM group (a–c) and IIM group (df). Notes: *P < 0.05. Actual p value and 95% CI are provided from a–f as follows: a (95% CI: −0.677, −0.151, p = 0.005), b (95% CI: 0.292, 0.750, p < 0.001), c (95% CI: 0.310, 0.758, p < 0.001), (d) (95% CI: 0.548, −0.060, p = 0.017), (e) (95% CI: 0.090, 0.568, p = 0.01), and (f) (95% CI: −0.033, 0.479, p = 0.084). CI: confidence interval; NT-proBNP, N-terminal pro-brain natriuretic peptide; GRPS, global radial peak strain; GCPS, global circumferential peak strain; GLPS, global longitudinal peak strain; IIM, idiopathic inflammatory myopathy.
Figure 2
Figure 2
Pearson’s correlation analysis of LVEF with GRPS, GCPS, and GLPS in the non-IIM group (ac) and IIM group (df). Notes: *P < 0.05. Actual p value and 95% CI are provided from (af) as follows: a (95% CI: 0.717, 0.910, p < 0.001), b (95% CI: −0.949, −0.831, p < 0.001), c (95% CI: 0.808, −0.457, p < 0.001), (d) (95% CI: 0.284, 0.686, p < 0.001), (e) (95% CI: −0.734, −0.370, p < 0.001), and (f) (95% CI: −0.681, −0.274, p < 0.001). Abbreviations as in Table 1 and Fig. 1.
Figure 3
Figure 3
Cardiac MRI tissue tracking in the four-chamber long-axis, two-chamber long-axis and short-axis cine images at the end-diastole (ac) and end-systole (df). The red and green curves show the endocardial and epicardial borders, respectively; the yellow dots represent the myocardial voxel points. Abbreviations: MRI, magnetic resonance imaging.

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