Transfusion Medicine Equations Made Internet Accessible

Transfus Med Rev. 2020 Jan;34(1):5-9. doi: 10.1016/j.tmrv.2019.10.003. Epub 2019 Nov 16.


Multiple mathematical equations inform the practice of transfusion medicine. These equations apply to a wide range of topics: dosage of blood products, calculation of fluid volumes, and even specific treatment decisions (e.g. corrected count increment for determination of platelet refractoriness). The calculation of these equations can be complicated, prone to error, and time-consuming. A trusted source is needed to accurately perform these calculations 24 hours a day without error and without monetary cost. We sought to build internet-enabled calculators relevant to the practice of transfusion medicine. We partnered with MDCalc, an online host of medical calculators with 1 million monthly users in 196 countries, to design and host the calculators. The calculators guide users in the application of transfusion medicine equations by providing indications for use, inputs for the equations variables, error-checking, warnings for bad inputs, and interpretive guidance of the result. The following calculators were built: blood volume, corrected count increment (CCI), plasma dosage, cryoprecipitated antihemophilic factor dosage, approximate number of units for compatibility testing, maternal-fetal hemorrhage Rh(D) immune globulin dosage, intrauterine RBC transfusion dosage, neonatal polycythemia partial exchange, theoretical removal of a substance by plasmapheresis, sickle cell RBC exchange volume, peripheral blood stem cell collection, and a calculator relevant to donor lymphocyte infusion. Clinicians can now utilize this reputable and highly visible online source to access these common transfusion medicine equations at any time with an internet-enabled device (

Keywords: Blood transfusion; Computers; Internet.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Costs and Cost Analysis
  • Decision Making, Computer-Assisted*
  • Erythrocyte Transfusion / economics
  • Erythrocyte Transfusion / methods
  • Erythrocyte Transfusion / trends
  • Humans
  • Internet*
  • Models, Theoretical*
  • Plasma Exchange / economics
  • Plasma Exchange / methods
  • Plasma Exchange / trends
  • Platelet Transfusion / economics
  • Platelet Transfusion / methods
  • Platelet Transfusion / trends
  • Practice Patterns, Physicians' / economics
  • Practice Patterns, Physicians' / trends
  • Transfusion Medicine* / economics
  • Transfusion Medicine* / methods
  • Transfusion Medicine* / organization & administration
  • Transfusion Medicine* / trends