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Case Reports
. 2019 Sep 27;7(11):2076-2081.
doi: 10.1002/ccr3.2401. eCollection 2019 Nov.

Parvovirus B19-induced Hemophagocytic Lymphohistiocytosis: Case Report and Review of the Literature

Free PMC article
Case Reports

Parvovirus B19-induced Hemophagocytic Lymphohistiocytosis: Case Report and Review of the Literature

James Kalmuk et al. Clin Case Rep. .
Free PMC article


HLH is a catastrophic and likely underdiagnosed pathology with multiple triggers including infection. PVB19 can cause persistent marrow infection leading to HLH despite negative acute serologic markers making timely diagnosis difficult. Increased awareness of PVB19-HLH is warranted given its potentially lethal nature and the careful interpretation required with serologic markers.

Keywords: Parvovirus B19; bone marrow; hemophagocytic lymphohistiocytosis; viral serology.

Conflict of interest statement

None declared.


Figure 1
Figure 1
Bone marrow aspirate demonstrating large erythroblasts (arrows) with vacuolated cytoplasm and nuclear inclusions consistent with Parvovirus B19 infection

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