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Risk Factor Analysis of the Decrease in Gait Speed Among Japanese Older Outpatients With Polypharmacy


Risk Factor Analysis of the Decrease in Gait Speed Among Japanese Older Outpatients With Polypharmacy

Masataka Deguchi et al. J Pharm Health Care Sci.


Background: Both polypharmacy and frailty are critical issues faced by the elderly. The decrease in gait speed is an index of frailty, and it is generally associated with falls and fractures, which are risk factors requiring the need for support or long-term patient care. In this study, we assess the risk factors responsible for the decrease in gait speed in older outpatients with polypharmacy.

Methods: Thirty-one persons (13 men, 18 women) aged 65 years or above and regularly taking 5 or more internal medications participated in this study.

Results: Propensity score-adjusted multivariate logistic analysis showed that only number of medications was associated with the risk of decreasing gait speed (odds ratio: 16.00, 95% confidence interval:1.72-149.00, p value = 0.0149). A negative correlation was found between the number of medications and gait speed. In addition, the gait speed of the calcium channel blocker medication group was significantly slower than that of the non-medication group.

Conclusion: These results suggest that not only the number of medications but also the prescription contents is a risk factor for decrease in gait speed and may serve as indexes to identify patients at high risk of requiring support or long-term care.

Keywords: Calcium channel blocker; Gait speed; Older outpatients; Polypharmacy; Prescription contents; Stratum corneum moisture content.

Conflict of interest statement

Competing interestsThe authors declare that they have no competing interests.


Fig. 1
Fig. 1
Correlation between number of medications and gait speed. Examined by the Spearman’s correlation coefficient
Fig. 2
Fig. 2
Patients were rearranged in order of gait speed, cells with the therapeutic category number corresponding to the medication being taken are shown in black. The lower the row the higher the gait speed

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    1. Statistics Bureau, Ministry of internal affairs and Communications . Population Estimates. 2019.
    1. The Japan Geriatrics Society . Guidelines for Medical Treatment and Its Safety in the Elderly 2015. Tokyo: The Japan Geriatrics Society, Medical View Co., Ltd; 2015. pp. 12–16.
    1. Fulton MM, Allen ER. Polypharmacy in the elderly: a literature review. J Am Acad Nurse Pract. 2005;17:123–132. doi: 10.1111/j.1041-2972.2005.0020.x. - DOI - PubMed
    1. Kojima T, Akishita M, Nakamura T, Nomura K, Ogawa S, Iijima K, Ouchi Y. Polypharmacy as a risk for fall occurrence in geriatric outpatients. Geriatr Gerontol Int. 2012;12:425–430. doi: 10.1111/j.1447-0594.2011.00783.x. - DOI - PubMed
    1. Kojima T, Akishita M, Kameyama Y, Yamaguchi K, Yamamoto H, Eto M, Ouchi Y. High risk of adverse drug reactions in elderly patients taking six or more drugs: analysis of inpatient database. Geriatr Gerontol Int. 2012;12:761–762. doi: 10.1111/j.1447-0594.2012.00868.x. - DOI - PubMed

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